Disruption of Blood–Brain Barrier by Focused Ultrasound for Targeted Drug Delivery to the Brain

A chapter about blood-brain barrier by focused ultrasound has been published in the new book entitled:  Drug Delivery to the Central Nervous System.
A detailed description of the method for MR-guided focal blood-brain barrier disruption (BBBD) in animals is described in this chapter.

A major challenge to drug delivery in the brain is caused by the blood-brain barrier (BBB).  Current strategies for overcoming the BBB are invasive and non-targeted.  As an alternative, non-invasive transietn and local image-guided BBBD can be accomplished using focused ultrasound (FUS).  Evaluation in vivo using MR guided focused ultrasound (MRgFUS) showed minimal adverse effects, as compared to invasive interventions.

To read the complete abstract of the chapter click here.